HitPredict

Interactor 1: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Interactor 2: STK11 (Q15831)
Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)
Gene: STK11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.884

The method score is based on:

Property Details
Experiments 16912160, 31217475, 31995728, 22575644
Identification Methods two hybrid, enzymatic study, affinity chromatography technology, pull down
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains AdenylateSensor~Pkinase, Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 9 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 559
Hs

1 433
+ Hs
+ Dm
+ At
+ At
+ At
+ Hs
+ At
+ At
+ At
+ At
+ Zm
+ Hs
+ Rn
+ Hs
+ Hs
+ At
+ At
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024