HitPredict

Interactor 1: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Interactor 2: SIK3 (Q9Y2K2)
Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)
Gene: SIK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16306228
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AdenylateSensor~Pkinase, Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0006468 - protein phosphorylation GO:0050321 - tau-protein kinase activity and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 559 Hs			1 1321
+	Hs
		647883 AAPK1_HUMAN (1-559): 0: 595: 100.00		MARK3_HUMAN (1-694): 4.86e-154: 484: 30.98
+	Hs
		1025211 AAPK1_HUMAN (1-559): 0: 595: 100.00		SIK2_HUMAN (50-831): 1.65e-151: 483: 34.99
+	Hs
		1025158 AAPK1_HUMAN (1-559): 0: 595: 100.00		MARK2_HUMAN (15-704): 3.17e-143: 457: 30.38
+	Hs
		1025197 AAPK1_HUMAN (1-559): 0: 595: 100.00		MARK4_HUMAN (1-716): 1.15e-143: 457: 30.76
+	Hs
		883219 AAPK1_HUMAN (1-559): 0: 595: 100.00		SIK1_HUMAN (50-805): 2.9e-138: 443: 31.73
+	Hs
		1025223 AAPK1_HUMAN (1-559): 0: 595: 100.00		SNRK_HUMAN (52-427): 1.48e-137: 441: 38.85
+	Hs
		871372 AAPK1_HUMAN (1-559): 0: 595: 100.00		AAPK2_HUMAN (52-589): 2.46e-139: 438: 30.39
+	Hs
		1025125 AAPK1_HUMAN (1-559): 0: 595: 100.00		AAPK1_HUMAN (44-598): 1.69e-138: 436: 28.91
+	Rn
		871200 AAPK1_RAT (1-559): 0: 593: 99.11		AAPK1_RAT (44-599): 4.74e-138: 435: 28.98
+	Hs
		871349 AAPK2_HUMAN (13-559): 0: 535: 75.41		AAPK2_HUMAN (52-589): 2.46e-139: 438: 30.39
+	Hs
		1025228 AAPK1_HUMAN (1-559): 0: 595: 100.00		MARK1_HUMAN (41-382): 1.92e-105: 354: 55.43
+	At
		1105318 KIN10_ARATH (26-454): 1.27e-163: 477: 50.35		KIN10_ARATH (51-436): 1.59e-148: 461: 38.52
+	Hs
		647915 MARK2_HUMAN (10-545): 5.04e-150: 451: 29.64		MARK3_HUMAN (1-694): 4.86e-154: 484: 30.98
+	At
		955190 KIN10_ARATH (26-454): 1.27e-163: 477: 50.35		KIN11_ARATH (65-422): 2.05e-144: 450: 40.95
+	At
		1103380 CIPK3_ARATH (16-498): 2.2e-154: 451: 31.89		CIPK3_ARATH (55-470): 1.4e-145: 450: 32.16
+	Hs
		258840 MARK2_HUMAN (10-545): 5.04e-150: 451: 29.64		O75271_HUMAN (1-436): 3.24e-139: 434: 42.56
+	Hs
		1025164 AAPK1_HUMAN (1-559): 0: 595: 100.00		BRSK2_HUMAN (63-398): 9.43e-78: 275: 43.49