HitPredict

Interactor 1: NR1H3 (Q13133)
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
Gene: NR1H3

Interactor 2: NCOR2 (Q9Y618)
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
Gene: NCOR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	26120082
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 447 Hs			1 2514
+	Hs
		587211 RXRA_HUMAN (6-445): 5.73e-129: 382: 22.89		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		818890 RXRG_HUMAN (2-444): 2.88e-127: 378: 24.18		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		874405 NR1H2_HUMAN (12-447): 3.47e-127: 377: 61.96		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		370824 ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		1069095 Q15156_HUMAN (96-447): 1.84e-112: 350: 33.33		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		500380 RARB_HUMAN (14-447): 3.03e-114: 344: 28.25		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		261493 NR1H3_HUMAN (1-447): 1.97e-151: 439: 100.00		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261399 RXRA_HUMAN (6-445): 5.73e-129: 382: 22.89		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261450 NR1H2_HUMAN (12-447): 3.47e-127: 377: 61.96		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261369 ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261429 HNF4A_HUMAN (74-443): 1.56e-112: 340: 26.08		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Mm
		1206787 NR1H3_MOUSE (1-447): 1.73e-143: 419: 90.83		Q8BK32_MOUSE (1-280): 1.47e-40: 155: 49.66
+	Hs
		370417 ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04		TARA_HUMAN (40-1577): 3.75e-52: 206: 9.68
+	Mm
		1142685 ERR2_MOUSE (9-446): 1.81e-113: 342: 23.41		RCOR1_MOUSE (378-704): 1.76e-42: 166: 22.35
+	Hs
		370728 ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		370263 ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		370251 ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		370040 ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04		KMT2C_HUMAN (679-1264): 4.24e-16: 88: 11.93
+	Hs
		490111 COT1_HUMAN (20-443): 7.12e-114: 342: 25.47		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		370105 ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04		TITIN_HUMAN (1125-2056): 5.55e-11: 70.9: 8.61