HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	30773093, 36950384
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 414 Hs			1 763
+	Hs
		162042 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		852052 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		201668 MSI1H_HUMAN (96-409): 4.25e-61: 203: 23.93		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1031320 PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		516508 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1043782 HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1044035 MSI2H_HUMAN (41-207): 5.16e-20: 92.2: 23.81		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		161966 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72
+	Zm
		11850 A0A1D6II08_MAIZE (100-398): 7.67e-61: 207: 25.77		A0A1D6FHK3_MAIZE (103-525): 7.64e-118: 362: 22.50
+	Sc
		376610 PABP_YEAST (86-269): 2.74e-34: 136: 21.88		YAK1_YEAST (19-586): 3.53e-116: 371: 29.05
+	Hs
		516362 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Zm
		9779 A0A1D6EZQ5_MAIZE (2-411): 2.75e-27: 115: 14.93		A0A1D6FHK3_MAIZE (103-525): 7.64e-118: 362: 22.50
+	Hs
		415020 MSI2H_HUMAN (41-207): 5.16e-20: 92.2: 23.81		CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57
+	Hs
		625424 HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85