HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: PABP2 (Q86U42)
Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)
Gene: PABPN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20720006
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 414 Hs			1 306
+	Hs
		62530 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		RFOX3_HUMAN (75-301): 1.74e-33: 126: 17.80
+	Hs
		516491 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		1025728 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Hs
		851999 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		161948 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		62520 MSI1H_HUMAN (96-409): 4.25e-61: 203: 23.93		RFOX3_HUMAN (75-301): 1.74e-33: 126: 17.80
+	Hs
		162035 HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Hs
		516424 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		474021 PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Hs
		853881 PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Sp
		145447 PABP_SCHPO (87-269): 2.44e-34: 136: 20.42		PAB2_SCHPO (107-255): 3.12e-34: 124: 48.32
+	Sc
		376818 PABP_YEAST (86-269): 2.74e-34: 136: 21.88		SGN1_YEAST (116-301): 3.31e-32: 121: 25.00
+	Hs
		516495 PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Mm
		665745 TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92		PABP1_MOUSE (59-260): 4.17e-22: 98.4: 11.33
+	Hs
		680422 TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76		TIA1_HUMAN (167-278): 4.88e-19: 88.4: 15.93
+	Sc
		376562 PABP_YEAST (86-269): 2.74e-34: 136: 21.88		PABP_YEAST (143-260): 3.27e-19: 89.6: 20.17
+	Hs
		516339 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		516689 PABP3_HUMAN (2-382): 7.84e-31: 126: 16.41		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Sc
		376785 PABP_YEAST (86-269): 2.74e-34: 136: 21.88		HRB1_YEAST (153-268): 1.5e-16: 81.4: 29.51
+	Sc
		376694 PABP_YEAST (86-269): 2.74e-34: 136: 21.88		PUB1_YEAST (165-255): 5.29e-09: 58.8: 18.48