HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: XRN2 (Q9H0D6)
5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein)
Gene: XRN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.661

Property	Details
Experiments	15231747, 20020773, 32814053
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 414 Hs			1 950
+	Hs
		852164 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		XRN2_HUMAN (1-950): 0: 1552: 100.00
+	Hs
		1025834 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		XRN1_HUMAN (1-685): 0: 848: 38.70
+	Hs
		1031389 PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02		XRN1_HUMAN (1-685): 0: 848: 38.70
+	Sc
		376636 PABP_YEAST (86-269): 2.74e-34: 136: 21.88		XRN1_YEAST (1-702): 0: 792: 34.21
+	Sc
		376906 PABP_YEAST (86-269): 2.74e-34: 136: 21.88		XRN2_YEAST (405-884): 5.45e-95: 324: 30.39