HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	33277362, 23541532
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0140693 - molecular condensate scaffold activity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 414 Hs			1 624
+	Hs
		1026014 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		852196 ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		1031489 PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		680496 TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Dm
		1375071 Q9W1I0_DROME (4-323): 2.53e-60: 200: 50.00		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Hs
		516729 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		1025833 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		UBQLN_HUMAN (5-445): 3.18e-75: 249: 33.00
+	Hs
		803509 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Hs
		1025782 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		803528 HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23