HitPredict

Interactor 1: FADD (Q13158)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
Gene: FADD

Interactor 2: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 26186194, 26865630, 24098568, 27560715, 29497034, 30561431, 32024820, 33961781, 33469115, 37085671, 21183682, 21620750, 22848449, 21052097, 21458669, 22864571, 23972990, 26972597, 26733177, 23744296 and 13 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, anti bait coimmunoprecipitation, virotrap, validated two hybrid
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death
Common GO terms GO:0005123 - death receptor binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
GO:0031264 - death-inducing signaling complex
and 14 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 208
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024