HitPredict

Interactor 1: FADD (Q13158)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
Gene: FADD

Interactor 2: MYD88 (Q99836)
Myeloid differentiation primary response protein MyD88
Gene: MYD88

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.829

The method score is based on:

Property	Details
Experiments	21988832, 17785432, 10880445
Identification Methods	two hybrid, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Death~Death
Common GO terms	GO:0005123 - death receptor binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006915 - apoptotic process and 9 others more... GO:0032757 - positive regulation of interleukin-8 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0035591 - signaling adaptor activity GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051607 - defense response to virus GO:0060090 - molecular adaptor activity GO:0071260 - cellular response to mechanical stimulus
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	208
Hs

1	296

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024