HitPredict

Interactor 1: FADD (Q13158)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
Gene: FADD

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.65 0.60 0.628

The method score is based on:

Property Details
Experiments 30561431, 21458669
Identification Methods affinity chromatography technology, virotrap, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process
GO:0035591 - signaling adaptor activity
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
and 2 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 208
Hs

1 419
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024