HitPredict

Interactor 1: PAK2 (Q13177)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Gene: PAK2

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019901 - protein kinase binding GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 524 Hs			1 191
+	Hs
		436282 PAK2_HUMAN (1-524): 0: 538: 100.00		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		915646 PAK2_HUMAN (1-524): 0: 538: 100.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		925245 PAK2_HUMAN (1-524): 0: 538: 100.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		564507 PAK2_HUMAN (1-524): 0: 538: 100.00		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		893958 PAK2_HUMAN (1-524): 0: 538: 100.00		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Mm
		925809 PAK2_MOUSE (1-524): 0: 531: 97.14		RAC1_MOUSE (2-191): 2.63e-75: 226: 39.09
+	Hs
		545351 PAK2_HUMAN (1-524): 0: 538: 100.00		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		892346 PAK2_HUMAN (1-524): 0: 538: 100.00		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		950964 PAK2_HUMAN (1-524): 0: 538: 100.00		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		900433 PAK2_HUMAN (1-524): 0: 538: 100.00		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Rn
		1145152 PAK2_RAT (1-524): 0: 530: 96.95		CDC42_RAT (2-181): 1.52e-73: 221: 42.25
+	Mm
		103566 G5E884_MOUSE (1-523): 2.64e-169: 491: 74.95		RAC1_MOUSE (2-191): 2.63e-75: 226: 39.09
+	Mm
		103565 G5E884_MOUSE (1-523): 2.64e-169: 491: 74.95		CDC42_MOUSE (2-181): 1.52e-73: 221: 42.25
+	Hs
		564505 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Rn
		723755 PAK1_RAT (1-523): 2.1e-169: 491: 75.14		CDC42_RAT (2-181): 1.52e-73: 221: 42.25
+	Mm
		103567 G5E884_MOUSE (1-523): 2.64e-169: 491: 74.95		RAC2_MOUSE (2-191): 6.79e-73: 220: 38.58
+	Hs
		893957 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545350 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		892345 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Mm
		103575 G5E884_MOUSE (1-523): 2.64e-169: 491: 74.95		RHOQ_MOUSE (5-190): 6.53e-71: 215: 39.49