HitPredict

Interactor 1: PAK2 (Q13177)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Gene: PAK2

Interactor 2: SH3R3 (Q8TEJ3)
E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)
Gene: SH3RF3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.50	0.528

Property	Details
Experiments	16374509
Identification Methods	pull down, filter binding, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 524 Hs			1 882
+	Hs
		1026928 PAK2_HUMAN (1-524): 0: 538: 100.00		SH3R1_HUMAN (46-882): 1.03e-98: 330: 42.17
+	Hs
		682191 AKT2_HUMAN (141-523): 2.01e-138: 410: 22.79		SH3R1_HUMAN (46-882): 1.03e-98: 330: 42.17
+	Hs
		1026922 PAK2_HUMAN (1-524): 0: 538: 100.00		SPD2A_HUMAN (59-881): 2.54e-21: 102: 10.28
+	Hs
		1026910 PAK2_HUMAN (1-524): 0: 538: 100.00		ARHG6_HUMAN (769-882): 3.47e-19: 94.9: 19.30
+	Hs
		298975 PAK2_HUMAN (1-524): 0: 538: 100.00		SRBS2_HUMAN (523-882): 1.7e-18: 93.2: 14.79
+	Hs
		1026904 PAK2_HUMAN (1-524): 0: 538: 100.00		ARHG7_HUMAN (829-882): 7.71e-16: 84.1: 37.04
+	Hs
		81635 PAK2_HUMAN (1-524): 0: 538: 100.00		B7Z6G2_HUMAN (829-882): 1.68e-15: 82.9: 37.04
+	Hs
		235500 PAK2_HUMAN (1-524): 0: 538: 100.00		VINEX_HUMAN (686-879): 3.03e-14: 79.1: 20.62
+	Hs
		1026936 PAK2_HUMAN (1-524): 0: 538: 100.00		SH3K1_HUMAN (705-882): 2.04e-12: 72.9: 18.23
+	Hs
		1026944 PAK2_HUMAN (1-524): 0: 538: 100.00		SRBS1_HUMAN (122-250): 1.3e-09: 64.4: 20.61
+	Hs
		1026167 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		ARHG6_HUMAN (769-882): 3.47e-19: 94.9: 19.30
+	Hs
		1026158 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		ARHG7_HUMAN (829-882): 7.71e-16: 84.1: 37.04
+	Mm
		292047 PAK1_MOUSE (1-523): 1.84e-167: 486: 73.35		ARHG7_MOUSE (778-882): 2.26e-14: 79.5: 20.95
+	Hs
		1026202 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		SH3K1_HUMAN (705-882): 2.04e-12: 72.9: 18.23
+	Rn
		223051 PAK1_RAT (1-523): 2.1e-169: 491: 75.14		ARHG7_RAT (828-882): 1.39e-11: 70.5: 34.55
+	Hs
		277605 PAK3_HUMAN (1-523): 8.9e-162: 472: 71.71		ARHG7_HUMAN (829-882): 7.71e-16: 84.1: 37.04
+	Mm
		1142068 PAK3_MOUSE (1-523): 1.14e-162: 475: 71.35		ARHG7_MOUSE (778-882): 2.26e-14: 79.5: 20.95
+	Hs
		277606 PAK3_HUMAN (1-523): 8.9e-162: 472: 71.71		ITSN1_HUMAN (571-882): 3.18e-13: 76.4: 8.31
+	Hs
		298951 AKT2_HUMAN (141-523): 2.01e-138: 410: 22.79		SRBS2_HUMAN (523-882): 1.7e-18: 93.2: 14.79
+	Hs
		235479 AKT2_HUMAN (141-523): 2.01e-138: 410: 22.79		VINEX_HUMAN (686-879): 3.03e-14: 79.1: 20.62