HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	34079125, 31753913, 30554943
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 726
+	Hs
		631418 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		800386 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		949788 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		631371 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		631399 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		1067203 CDYL_HUMAN (16-165): 6.53e-34: 127: 25.16		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		123251 CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		123181 CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		1027327 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21
+	Hs
		998641 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		1027324 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BRPF3_HUMAN (37-484): 7.42e-31: 132: 14.82
+	Hs
		800357 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		949762 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		244377 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		1027151 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PHIP_HUMAN (5-708): 5.37e-19: 94.5: 10.37
+	Hs
		244073 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		244280 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		123146 CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		243752 CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		244962 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56