HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: YAF2 (Q8IY57)
YY1-associated factor 2
Gene: YAF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	27705803, 12004135, 24981860, 22325352
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 180
+	Hs
		949839 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1027119 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		949841 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		123282 CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		316090 CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1222225 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1059172 CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		123287 CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		316094 CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		1233210 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Mm
		675499 CBX2_MOUSE (20-117): 6.27e-26: 104: 27.00		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Hs
		1059175 CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78