HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: EHMT2 (Q96KQ7)
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
Gene: EHMT2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.749

Property	Details
Experiments	27705803, 24981860, 34079125, 33961781, 22514736, 17962312, 15200951
Identification Methods	affinity chromatography technology, proximity labelling technology, unspecified method, x-ray crystallography, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1210
+	Mm
		1322180 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EHMT2_MOUSE (9-1210): 0: 870: 94.44
+	Hs
		800497 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		EHMT2_HUMAN (21-1210): 0: 909: 100.00
+	Hs
		949863 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		EHMT2_HUMAN (21-1210): 0: 909: 100.00
+	Mm
		1143050 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		EHMT2_MOUSE (9-1210): 0: 870: 94.44
+	Mm
		1125433 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EHMT1_MOUSE (1-1209): 0: 692: 45.04
+	Hs
		1027268 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		EHMT1_HUMAN (1-1209): 0: 685: 45.63
+	Hs
		800530 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		EHMT1_HUMAN (1-1209): 0: 685: 45.63
+	Hs
		949889 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		EHMT1_HUMAN (1-1209): 0: 685: 45.63
+	Hs
		1027262 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Mm
		222468 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		SUV91_MOUSE (863-1177): 5.92e-84: 281: 30.95
+	Mm
		222460 CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45		SUV91_MOUSE (863-1177): 5.92e-84: 281: 30.95
+	Mm
		613035 CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45		SUV92_MOUSE (928-1177): 5.95e-82: 278: 36.30
+	Hs
		203674 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Hs
		1331984 V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		800527 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Mm
		222467 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		SUV91_MOUSE (863-1177): 5.92e-84: 281: 30.95
+	Hs
		949887 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		203638 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Hs
		203823 V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Hs
		203662 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51