HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	27705803, 24981860, 33961781, 24457600, 22325352
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000791 - euchromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 336
+	Mm
		1321739 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Mm
		613033 CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Hs
		987963 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		1027278 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67
+	Hs
		1027226 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		717776 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718395 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		1027025 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PCGF3_HUMAN (36-334): 3.56e-44: 153: 18.15
+	Hs
		1027218 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		1027241 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		1027092 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PCGF5_HUMAN (34-334): 1.89e-39: 141: 15.24
+	Mm
		1307910 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		PCGF6_MOUSE (26-296): 1.67e-36: 136: 14.23
+	Hs
		749443 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		800532 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67
+	Hs
		717529 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		800503 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		800514 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Mm
		1143044 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		PCGF6_MOUSE (26-296): 1.67e-36: 136: 14.23
+	Hs
		749196 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		749372 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79