HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: PCGF6 (Q9BYE7)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	27705803, 24981860, 12004135, 28514442, 33961781, 22325352
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 350
+	Mm
		1307910 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		PCGF6_MOUSE (41-350): 5.4e-85: 262: 92.90
+	Hs
		800514 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		PCGF6_HUMAN (1-350): 1.95e-96: 291: 100.00
+	Hs
		949876 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		PCGF6_HUMAN (1-350): 1.95e-96: 291: 100.00
+	Hs
		717776 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Mm
		1143044 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		PCGF6_MOUSE (41-350): 5.4e-85: 262: 92.90
+	Mm
		949960 CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33		PCGF6_MOUSE (41-350): 5.4e-85: 262: 92.90
+	Hs
		718395 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Hs
		1027025 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Hs
		1027226 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		717529 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		1027092 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Hs
		949871 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Mm
		1321739 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		1027216 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Mm
		613033 CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		987963 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Hs
		949867 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		949760 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Mm
		1164651 Q6TKP2_MOUSE (21-124): 1.37e-30: 118: 27.78		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Mm
		1321737 CBX6_MOUSE (21-124): 3.07e-29: 112: 27.78		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49