HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: WDR76 (Q9H967)
WD repeat-containing protein 76
Gene: WDR76

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	27248496, 31353912
Identification Methods	affinity chromatography technology, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0006974 - DNA damage response GO:0019899 - enzyme binding GO:0090734 - site of DNA damage
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 626
+	Hs
		800529 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		WDR76_HUMAN (1-626): 1.19e-151: 453: 100.00
+	Hs
		949888 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		WDR76_HUMAN (1-626): 1.19e-151: 453: 100.00
+	Hs
		800458 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		DAW1_HUMAN (132-575): 2.76e-78: 256: 14.87
+	Hs
		203735 SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20		DAW1_HUMAN (132-575): 2.76e-78: 256: 14.87
+	Hs
		903191 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		1281401 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		903125 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		1335779 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		NLE1_HUMAN (181-575): 1.3e-63: 219: 12.70
+	Hs
		997703 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Mm
		222466 SUV91_MOUSE (3-179): 2.61e-41: 145: 17.32		RBBP7_MOUSE (311-580): 1.59e-37: 146: 15.31
+	Mm
		1141931 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		RBBP4_MOUSE (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		800356 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		949761 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		1288395 CDYL_HUMAN (16-165): 6.53e-34: 127: 25.16		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	Hs
		903532 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		1288317 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	Mm
		222465 SUV91_MOUSE (3-179): 2.61e-41: 145: 17.32		RBBP4_MOUSE (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		1059181 CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	Hs
		203672 SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		997961 CDYL_HUMAN (16-165): 6.53e-34: 127: 25.16		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55