HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: TF7L2 (Q9NQB0)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Gene: TCF7L2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30833792
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 619
+	Hs
		316171 CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78		TF7L2_HUMAN (1-619): 4e-84: 277: 100.00
+	Hs
		1027207 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		331801 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		NSD2_HUMAN (251-564): 1.22e-30: 130: 13.97
+	Hs
		996646 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Mm
		818771 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15
+	Hs
		800501 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Mm
		818718 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15
+	Dm
		1363173 Q9VCU6_DROME (25-170): 2.08e-46: 153: 39.46		Q9VUD3_DROME (302-514): 2.02e-31: 131: 19.07
+	Mm
		818693 CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33		SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15
+	Dm
		114467 Q9VCU6_DROME (25-170): 2.08e-46: 153: 39.46		M9PCG2_DROME (302-514): 6.35e-30: 126: 19.07
+	Hs
		175775 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		HMGB3_HUMAN (354-438): 3.21e-09: 59.2: 17.24
+	Hs
		727806 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		SOX5_HUMAN (3-485): 3.95e-38: 152: 12.73
+	Hs
		123201 CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		996672 CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Hs
		818053 CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69