HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: TRI33 (Q9UPN9)
E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)
Gene: TRIM33

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	34079125, 20603019
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Chromo~PHD
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1127
+	Hs
		949915 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		TRI33_HUMAN (1-1127): 0: 679: 100.00
+	Mm
		1145016 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		TIF1A_MOUSE (106-1127): 1.59e-146: 469: 43.82
+	Hs
		170353 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		TIF1A_HUMAN (106-1127): 7.13e-146: 467: 44.94
+	Mm
		1143020 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		TIF1A_MOUSE (106-1127): 1.59e-146: 469: 43.82
+	Hs
		170295 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		TIF1A_HUMAN (106-1127): 7.13e-146: 467: 44.94
+	Mm
		949937 CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33		TIF1A_MOUSE (106-1127): 1.59e-146: 469: 43.82
+	Hs
		170331 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		TIF1A_HUMAN (106-1127): 7.13e-146: 467: 44.94
+	Hs
		1027278 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		TRI39_HUMAN (172-439): 1.14e-52: 195: 14.71
+	Hs
		1027317 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BAZ2A_HUMAN (886-1085): 3.19e-44: 177: 26.80
+	Mm
		1266178 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		TRI66_MOUSE (427-1126): 5.25e-41: 167: 20.43
+	Hs
		800532 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		TRI39_HUMAN (172-439): 1.14e-52: 195: 14.71
+	Hs
		949891 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		TRI39_HUMAN (172-439): 1.14e-52: 195: 14.71
+	Mm
		1143042 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		TRI66_MOUSE (427-1126): 5.25e-41: 167: 20.43
+	Mm
		949959 CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33		TRI66_MOUSE (427-1126): 5.25e-41: 167: 20.43
+	Hs
		1026971 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20
+	Mm
		1143843 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		TIF1B_MOUSE (674-1105): 1.19e-23: 110: 18.62
+	Hs
		800365 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20
+	Mm
		1143019 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		TIF1B_MOUSE (674-1105): 1.19e-23: 110: 18.62
+	Hs
		949772 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20
+	Mm
		949936 CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33		TIF1B_MOUSE (674-1105): 1.19e-23: 110: 18.62