HitPredict

Interactor 1: STK3 (Q13188)
Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]
Gene: STK3

Interactor 2: STK3 (Q13188)
Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]
Gene: STK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.951

The method score is based on:

Property Details
Experiments 18082144, 28205554, 15618521, 20086174, 23972470, 20562859
Identification Methods enzymatic study, fluorescent resonance energy transfer, affinity chromatography technology, anti tag coimmunoprecipitation, molecular sieving, cosedimentation in solution, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Mst1_SARAH~Mst1_SARAH, Pkinase~Pkinase
Common GO terms GO:0000287 - magnesium ion binding
GO:0001841 - neural tube formation
GO:0003157 - endocardium development
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
and 38 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 491
Hs

1 491
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+ Gm
+ At
+ At
+ At
+ At
+ Rn
+ Hs
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Last updated: 15 Jul 2024