HitPredict

Interactor 1: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	0.60	0.596

Property	Details
Experiments	16228008, 12935897
Identification Methods	x-ray crystallography, two hybrid, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 982 Hs			1 803
+	Mm
		1112077 CBLB_MOUSE (1-982): 0: 873: 95.12		ARHG7_MOUSE (1-797): 0: 570: 91.09
+	Hs
		610397 CBL_HUMAN (25-976): 0: 675: 47.10		ARHG7_HUMAN (1-803): 0: 654: 100.00
+	Hs
		548699 CBLB_HUMAN (1-982): 0: 877: 100.00		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		855791 CBLB_HUMAN (1-982): 0: 877: 100.00		VAV2_HUMAN (1-712): 4.73e-111: 360: 17.04
+	Hs
		1027629 CBLB_HUMAN (1-982): 0: 877: 100.00		VAV3_HUMAN (1-731): 3.11e-110: 358: 16.73
+	Mm
		82736 B9EKI5_MOUSE (1-982): 0: 852: 90.53		VAV2_MOUSE (1-712): 1.26e-107: 351: 16.38
+	Hs
		610407 CBL_HUMAN (25-976): 0: 675: 47.10		ARHG6_HUMAN (1-802): 1.77e-161: 489: 51.48
+	Hs
		548639 CBL_HUMAN (25-976): 0: 675: 47.10		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		610308 CBL_HUMAN (25-976): 0: 675: 47.10		VAV2_HUMAN (1-712): 4.73e-111: 360: 17.04
+	Mm
		1112081 CBLB_MOUSE (1-982): 0: 873: 95.12		ITSN2_MOUSE (41-272): 1.94e-14: 79.8: 23.08
+	Hs
		1027627 CBLB_HUMAN (1-982): 0: 877: 100.00		ITSN2_HUMAN (41-259): 5.37e-11: 68.6: 18.55
+	Hs
		1027606 CBLB_HUMAN (1-982): 0: 877: 100.00		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68
+	Mm
		610657 CBL_MOUSE (25-976): 0: 674: 47.47		ITSN2_MOUSE (41-272): 1.94e-14: 79.8: 23.08
+	Hs
		610517 CBL_HUMAN (25-976): 0: 675: 47.10		ITSN2_HUMAN (41-259): 5.37e-11: 68.6: 18.55
+	Mm
		610656 CBL_MOUSE (25-976): 0: 674: 47.47		ITSN1_MOUSE (21-252): 1.33e-10: 67.4: 17.00
+	Hs
		610415 CBL_HUMAN (25-976): 0: 675: 47.10		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68
+	Ce
		136804 UNC89_CAEEL (332-806): 6.63e-13: 75.4: 10.27		VAV_CAEEL (2-676): 1.52e-78: 275: 16.64
+	Hs
		203228 SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68