HitPredict

Interactor 1: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	12692129, 35271311, 24158444, 11278995
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 908 Hs			1 1083
+	Hs
		1072709 PSMD1_HUMAN (59-845): 0: 790: 17.31		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		983117 PSMD2_HUMAN (1-908): 0: 1290: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		1027800 PSMD2_HUMAN (1-908): 0: 1290: 100.00		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		1027714 PSMD2_HUMAN (1-908): 0: 1290: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		983219 PSMD1_HUMAN (59-845): 0: 790: 17.31		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Sc
		753932 RPN1_YEAST (49-906): 0: 869: 37.71		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12
+	Hs
		1192180 PSMD1_HUMAN (59-845): 0: 790: 17.31		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Sc
		693333 RPN2_YEAST (59-841): 0: 679: 17.83		HUL5_YEAST (662-1083): 8.08e-75: 268: 39.07
+	Sc
		693352 RPN2_YEAST (59-841): 0: 679: 17.83		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12