HitPredict

Interactor 1: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Interactor 2: PAAF1 (Q9BRP4)
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)
Gene: PAAF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.671

Property	Details
Experiments	17353931, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 908 Hs			1 392
+	Hs
		1027700 PSMD2_HUMAN (1-908): 0: 1290: 100.00		Q6FHM2_HUMAN (64-350): 1.04e-69: 224: 22.56
+	Hs
		920952 PSMD2_HUMAN (1-908): 0: 1290: 100.00		GBB1_HUMAN (6-283): 1.85e-46: 164: 19.66
+	Hs
		903193 PSMD2_HUMAN (1-908): 0: 1290: 100.00		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Hs
		1303913 PSMD1_HUMAN (59-845): 0: 790: 17.31		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Sc
		753897 RPN1_YEAST (49-906): 0: 869: 37.71		COPA_YEAST (3-376): 1.92e-44: 166: 10.58
+	Sc
		753892 RPN1_YEAST (49-906): 0: 869: 37.71		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Sc
		693334 RPN2_YEAST (59-841): 0: 679: 17.83		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49