HitPredict

Interactor 1: NMDE2 (Q13224)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
Gene: GRIN2B

Interactor 2: DLG2 (Q15700)
Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)
Gene: DLG2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.648

Property	Details
Experiments	11997254, 9278515, 35914814
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0014069 - postsynaptic density GO:0043005 - neuron projection GO:0098839 - postsynaptic density membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1484 Hs			1 870
+	Rn
		962666 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG2_RAT (1-870): 0: 740: 94.94
+	Mm
		963769 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG2_MOUSE (1-870): 0: 740: 94.83
+	Hs
		1018896 NMDE1_HUMAN (9-1484): 0: 1495: 52.39		DLG2_HUMAN (1-870): 0: 755: 100.00
+	Rn
		962657 NMDE1_RAT (9-1484): 0: 1506: 52.59		DLG2_RAT (1-870): 0: 740: 94.94
+	Mm
		761851 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		ZO1_MOUSE (76-864): 1.64e-109: 372: 20.53
+	Hs
		1021485 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG1_HUMAN (266-573): 3.79e-18: 91.8: 17.83
+	Hs
		942337 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG4_HUMAN (375-573): 1.91e-16: 86: 22.93
+	Hs
		1028145 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG3_HUMAN (317-573): 1.1e-12: 74.1: 19.40
+	Rn
		962663 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG1_RAT (271-503): 5.38e-17: 87.9: 17.19
+	Rn
		677781 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG4_RAT (375-573): 1.69e-16: 86.4: 22.93
+	Mm
		963751 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG1_MOUSE (271-573): 6.98e-17: 87.6: 17.48
+	Rn
		962664 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG3_RAT (273-573): 1.44e-15: 83.3: 16.23
+	Mm
		963732 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG4_MOUSE (375-573): 1.94e-16: 86: 22.93
+	Mm
		936175 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG3_MOUSE (273-573): 2.97e-15: 82.5: 16.56
+	Mm
		723533 NMDE1_MOUSE (9-1484): 0: 1516: 52.79		DLG4_MOUSE (375-573): 1.94e-16: 86: 22.93
+	Rn
		962655 NMDE1_RAT (9-1484): 0: 1506: 52.59		DLG1_RAT (271-503): 5.38e-17: 87.9: 17.19
+	Rn
		677780 NMDE1_RAT (9-1484): 0: 1506: 52.59		DLG4_RAT (375-573): 1.69e-16: 86.4: 22.93
+	Rn
		962656 NMDE1_RAT (9-1484): 0: 1506: 52.59		DLG3_RAT (273-573): 1.44e-15: 83.3: 16.23
+	Hs
		1018888 NMDE1_HUMAN (9-1484): 0: 1495: 52.39		DLG1_HUMAN (266-573): 3.79e-18: 91.8: 17.83
+	Hs
		942334 NMDE1_HUMAN (9-1484): 0: 1495: 52.39		DLG4_HUMAN (375-573): 1.91e-16: 86: 22.93