Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2
Interactor 2: RIR2B (Q7LG56)
Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)
Gene: RRM2B
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.57 | 0.55 | 0.564 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 19015526 |
| Identification Methods | affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:1902254 - negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| Homologous interactions | 0 |
Service provided by Combinatics, Japan
Last updated: 11Aug2025
