HitPredict

Interactor 1: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Interactor 2: Q9UQC1 (Q9UQC1)
Heat shock protein 72
Gene: HSP70-1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1512 Hs			1 151
+	Hs
		564068 M3K1_HUMAN (1-1512): 0: 1994: 100.00		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33
+	Hs
		713957 M3K1_HUMAN (1-1512): 0: 1994: 100.00		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		504016 M3K1_HUMAN (1-1512): 0: 1994: 100.00		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		503390 KPCA_HUMAN (963-1509): 9.28e-133: 428: 18.93		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		397134 KPCG_HUMAN (899-1509): 4.13e-124: 405: 16.04		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33
+	Hs
		397128 KPCG_HUMAN (899-1509): 4.13e-124: 405: 16.04		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		397150 KPCG_HUMAN (899-1509): 4.13e-124: 405: 16.04		HSP77_HUMAN (1-150): 9.01e-76: 231: 81.33
+	Hs
		713942 CDK3_HUMAN (1243-1510): 4.87e-105: 338: 27.21		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		503902 CDK3_HUMAN (1243-1510): 4.87e-105: 338: 27.21		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		503460 CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		871753 M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03		HSP72_HUMAN (1-150): 8.81e-84: 259: 85.53
+	Hs
		564164 M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33
+	Hs
		1306402 M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		714056 M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		504640 M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Sc
		449916 STE11_YEAST (1208-1506): 9.69e-48: 185: 34.71		HSP73_YEAST (2-150): 8.28e-77: 241: 80.54
+	Hs
		871752 M3K5_HUMAN (1249-1503): 1.95e-40: 166: 37.31		HSP72_HUMAN (1-150): 8.81e-84: 259: 85.53
+	Sc
		490389 STE11_YEAST (1208-1506): 9.69e-48: 185: 34.71		HSP71_YEAST (1-150): 2.5e-75: 237: 78.67
+	Sc
		492146 BCK1_YEAST (1233-1506): 4.35e-44: 178: 39.01		HSP71_YEAST (1-150): 2.5e-75: 237: 78.67