HitPredict

Interactor 1: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Interactor 2: DOT1L (Q8TEK3)
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)
Gene: DOT1L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35850772
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 344 Hs			1 1537
+	Hs
		992856 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1256371 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1028584 SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		993780 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1028749 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1031399 PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1256430 RBM28_HUMAN (4-248): 1.53e-12: 70.6: 14.61		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		516603 PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		680470 TIA1_HUMAN (2-116): 2.8e-11: 66.1: 17.50		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		952054 SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84		DOT1L_HUMAN (1-1537): 0: 2441: 100.00