HitPredict

Interactor 1: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Interactor 2: SRPK3 (Q9UPE1)
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)
Gene: SRPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	23602568
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 344 Hs			1 567
+	Hs
		992994 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		SRPK3_HUMAN (27-567): 5.16e-140: 418: 100.00
+	Ce
		976971 RSP3_CAEEL (3-225): 9.74e-49: 166: 37.56		SPK1_CAEEL (18-567): 2.95e-122: 385: 48.31
+	Sp
		736982 SRP2_SCHPO (3-338): 7.51e-48: 167: 34.52		DSK1_SCHPO (3-565): 8.43e-109: 338: 35.27
+	Hs
		625590 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		942611 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		942916 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		942628 SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		942613 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		833870 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		992944 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		CLK4_HUMAN (45-228): 8.59e-63: 215: 30.81
+	Hs
		992896 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		833871 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		1302019 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		647674 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		MK03_HUMAN (65-267): 6e-45: 165: 21.60
+	Zm
		33400 A0A1D6M1U3_MAIZE (4-206): 9.28e-61: 200: 36.15		A0A1D6L2E7_MAIZE (69-220): 1.96e-11: 69.3: 33.33
+	Hs
		834026 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		833720 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		CLK1_HUMAN (405-566): 8.71e-11: 66.2: 26.01
+	Dm
		834188 Q9V3W7_DROME (3-188): 2.19e-50: 170: 36.84		DOA_DROME (396-566): 7.94e-12: 70.1: 25.41
+	Hs
		834027 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		833721 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		CLK1_HUMAN (405-566): 8.71e-11: 66.2: 26.01