HitPredict

Interactor 1: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0045087 - innate immune response
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 835 Hs			1 419
+	Hs
		734821 TRI23_HUMAN (38-421): 2.37e-56: 205: 14.42		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1318722 TRIM5_HUMAN (113-541): 7.42e-50: 185: 13.04		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1078905 TRIM8_HUMAN (59-589): 2.74e-56: 205: 16.09		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		585030 RO52_HUMAN (104-502): 1.58e-48: 180: 12.94		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		1078906 TRIM5_HUMAN (113-541): 7.42e-50: 185: 13.04		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Rn
		250674 TRIM3_RAT (122-628): 1.88e-53: 200: 15.66		MYO5B_RAT (61-394): 8.96e-25: 109: 17.85
+	Hs
		262202 TRIM3_HUMAN (122-628): 2.47e-53: 200: 15.85		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		551867 TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		164472 TRI66_HUMAN (335-810): 2.93e-45: 178: 19.00		SCAPE_HUMAN (25-345): 4.15e-29: 122: 16.91
+	Hs
		262200 TRIM3_HUMAN (122-628): 2.47e-53: 200: 15.85		MYO5B_HUMAN (64-394): 2.99e-18: 89.7: 16.95
+	Hs
		668471 PML_HUMAN (29-609): 1.21e-57: 214: 14.00		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		528385 TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		725074 TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		725269 TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		170277 TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		724991 TRI56_HUMAN (47-532): 1.21e-51: 195: 17.68		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		522639 TRIM6_HUMAN (113-494): 1.14e-47: 179: 10.23		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		528393 TRIM6_HUMAN (113-494): 1.14e-47: 179: 10.23		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48