HitPredict

Interactor 1: STX3 (Q13277)
Syntaxin-3
Gene: STX3

Interactor 2: VAMP3 (Q15836)
Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)
Gene: VAMP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.923

Property	Details
Experiments	26553929, 26186194, 28514442, 12828989, 33961781
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0031201 - SNARE complex GO:0043005 - neuron projection
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 289 Hs			1 100
+	Hs
		620262 STX1B_HUMAN (1-288): 3.94e-79: 243: 59.79		VAMP1_HUMAN (8-87): 1.27e-25: 93.9: 80.00
+	Rn
		699182 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		VAMP1_RAT (8-99): 1.05e-26: 96.6: 72.83
+	Hs
		699263 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		VAMP3_HUMAN (1-81): 1.11e-25: 93.5: 100.00
+	Mm
		898816 STX1B_MOUSE (1-288): 3.94e-79: 243: 59.79		VAMP2_MOUSE (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		898830 STX1B_HUMAN (1-288): 3.94e-79: 243: 59.79		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Rn
		699183 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		VAMP7_RAT (7-80): 2.77e-23: 90.4: 35.14
+	Hs
		620271 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP1_HUMAN (8-87): 1.27e-25: 93.9: 80.00
+	Hs
		261664 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP4_HUMAN (3-82): 3.5e-25: 93.5: 40.00
+	Rn
		699175 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		VAMP2_RAT (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		699254 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		306784 STX1B_HUMAN (1-288): 3.94e-79: 243: 59.79		VAMP5_HUMAN (11-80): 1.96e-20: 80.4: 38.57
+	Hs
		699284 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		VAMP8_HUMAN (6-82): 1.84e-22: 85: 35.07
+	Hs
		850569 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP7_HUMAN (7-79): 4.38e-23: 90: 31.51
+	Mm
		192845 STX1A_MOUSE (1-287): 5.47e-77: 237: 63.45		VAMP2_MOUSE (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		263179 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		SC22B_HUMAN (8-97): 4.57e-21: 84.7: 25.56
+	Rn
		699186 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		VAMP8_RAT (6-78): 2.53e-22: 84.6: 35.62
+	Mm
		139056 STX1A_MOUSE (1-287): 5.47e-77: 237: 63.45		SC22B_MOUSE (8-97): 4.57e-21: 84.7: 25.56
+	Hs
		306763 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		VAMP5_HUMAN (11-80): 1.96e-20: 80.4: 38.57
+	Hs
		263248 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		SC22B_HUMAN (8-97): 4.57e-21: 84.7: 25.56
+	Hs
		306800 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP5_HUMAN (11-80): 1.96e-20: 80.4: 38.57