HitPredict

Interactor 1: STX3 (Q13277)
Syntaxin-3
Gene: STX3

Interactor 2: VAMP8 (Q9BV40)
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Gene: VAMP8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	29360461, 26186194, 26553929, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0031201 - SNARE complex GO:0042589 - zymogen granule membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 289 Hs			1 100
+	Dm
		1098086 STX1A_DROME (2-284): 1.93e-73: 228: 55.59		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Rn
		699183 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		VAMP7_RAT (1-100): 5.53e-27: 99: 40.00
+	Hs
		620262 STX1B_HUMAN (1-288): 3.94e-79: 243: 59.79		VAMP1_HUMAN (6-85): 1.02e-25: 93.8: 32.50
+	Rn
		699182 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		VAMP1_RAT (6-85): 9.7e-27: 96.5: 33.75
+	Dm
		577220 STX1A_DROME (2-284): 1.93e-73: 228: 55.59		SYB_DROME (5-95): 3.25e-30: 106: 27.47
+	Hs
		850569 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Mm
		898816 STX1B_MOUSE (1-288): 3.94e-79: 243: 59.79		VAMP2_MOUSE (6-82): 2.47e-23: 88: 35.07
+	Hs
		898830 STX1B_HUMAN (1-288): 3.94e-79: 243: 59.79		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Hs
		699263 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		699284 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		VAMP8_HUMAN (1-100): 2.94e-24: 89.6: 100.00
+	Hs
		620271 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP1_HUMAN (6-85): 1.02e-25: 93.8: 32.50
+	Hs
		261664 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Rn
		699175 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		VAMP2_RAT (6-82): 2.47e-23: 88: 35.07
+	Hs
		699254 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Mm
		192845 STX1A_MOUSE (1-287): 5.47e-77: 237: 63.45		VAMP2_MOUSE (6-82): 2.47e-23: 88: 35.07
+	Rn
		699186 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		VAMP8_RAT (3-76): 1.6e-22: 85.3: 94.60
+	Hs
		1079327 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		1083981 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP8_HUMAN (1-100): 2.94e-24: 89.6: 100.00
+	Hs
		926213 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Ce
		137701 STX1A_CAEEL (2-282): 5.06e-72: 225: 56.18		SYB1_CAEEL (8-82): 3.98e-24: 89.6: 33.33