HitPredict

Interactor 1: SLAF1 (Q13291)
Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150)
Gene: SLAMF1

Interactor 2: SHIP1 (Q92835)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)
Gene: INPP5D

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	11313386, 10229804
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032715 - negative regulation of interleukin-6 production
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 335 Hs			1 1189
+	Mm
		1322348 SLAF1_MOUSE (1-335): 1.89e-69: 222: 59.77		SHIP1_MOUSE (1-1189): 0: 858: 87.11
+	Hs
		1271567 SLAF7_HUMAN (5-334): 1e-59: 196: 19.46		SHIP1_HUMAN (1-1189): 0: 883: 100.00
+	Hs
		1271565 CD244_HUMAN (23-331): 5e-50: 172: 19.12		SHIP1_HUMAN (1-1189): 0: 883: 100.00
+	Hs
		1271566 LY9_HUMAN (10-246): 1.54e-43: 160: 22.54		SHIP1_HUMAN (1-1189): 0: 883: 100.00
+	Hs
		176495 CD244_HUMAN (23-331): 5e-50: 172: 19.12		SHIP2_HUMAN (3-1169): 0: 697: 39.77
+	Hs
		507956 FGFR1_HUMAN (20-333): 4.68e-46: 168: 9.12		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		601498 FGFR2_HUMAN (24-327): 1.1e-23: 103: 10.29		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		243137 SLAF1_HUMAN (1-335): 3.45e-80: 249: 100.00		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Mm
		292400 SLAF1_MOUSE (1-335): 1.89e-69: 222: 59.77		SH21A_MOUSE (7-116): 3.21e-22: 95.1: 44.55
+	Hs
		243158 SLAF7_HUMAN (5-334): 1e-59: 196: 19.46		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		243161 SLAF5_HUMAN (15-334): 6.3e-54: 181: 21.21		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		243155 CD244_HUMAN (23-331): 5e-50: 172: 19.12		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		243157 LY9_HUMAN (10-246): 1.54e-43: 160: 22.54		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		243153 SLAF6_HUMAN (13-330): 2.04e-43: 154: 18.04		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		203204 FGFR1_HUMAN (20-333): 4.68e-46: 168: 9.12		SYNJ1_HUMAN (720-1118): 4.38e-12: 73.1: 10.05
+	Hs
		243162 SIGL7_HUMAN (28-240): 1.96e-35: 135: 17.86		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26