HitPredict

Interactor 1: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Interactor 2: ATR (Q13535)
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)
Gene: ATR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.738

The method score is based on:

Property Details
Experiments 10608806, 17124492
Identification Methods unspecified method, enzymatic study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains FAT~FAT, FAT~FATC, FAT~PI3_PI4_kinase, FAT~UME, FATC~PI3_PI4_kinase, PI3_PI4_kinase~PI3_PI4_kinase
Common GO terms GO:0000077 - DNA damage checkpoint signaling
GO:0000723 - telomere maintenance
GO:0003677 - DNA binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
and 16 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 3056
Hs

1 2644
+ Hs
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+ Sp
+ Dm
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+ At
+ Sc
+ Hs
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+ Sp
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+ Sc

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Last updated: 15 Jul 2024