HitPredict

Interactor 1: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Interactor 2: 4EBP1 (Q13541)
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
Gene: EIF4EBP1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.617

Property	Details
Experiments	10608806, 10713094
Identification Methods	unspecified method, enzymatic study, in-gel kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 3056 Hs			1 118
+	Hs
		787477 MTOR_HUMAN (1846-3055): 0: 843: 16.65		4EBP1_HUMAN (1-118): 3.72e-61: 184: 100.00
+	Rn
		787620 MTOR_RAT (1846-3055): 0: 834: 16.58		4EBP1_RAT (1-118): 1.29e-58: 178: 92.37
+	Hs
		787478 MTOR_HUMAN (1846-3055): 0: 843: 16.65		4EBP2_HUMAN (2-118): 9.02e-52: 160: 57.14
+	Mm
		936815 MTOR_MOUSE (1846-3055): 0: 834: 16.65		4EBP2_MOUSE (2-118): 2.86e-53: 164: 57.98
+	Dm
		1369192 TOR_DROME (1644-3055): 0: 829: 17.31		4EBP_DROME (1-118): 1.68e-32: 111: 36.13
+	Dm
		1211964 TRA1_DROME (1871-3056): 0: 675: 13.65		4EBP_DROME (1-118): 1.68e-32: 111: 36.13
+	Hs
		944228 PRKDC_HUMAN (2005-3056): 6.86e-155: 545: 17.20		4EBP1_HUMAN (1-118): 3.72e-61: 184: 100.00