HitPredict

Interactor 1: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.921

The method score is based on:

Property Details
Experiments 12551896, 32296183, 31980649, 19648926, unassigned1304
Identification Methods x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, molecular sieving, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PH, PH~RA, RA~RA, SH2~SH2
Common GO terms GO:0005158 - insulin receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0008286 - insulin receptor signaling pathway
and 15 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 594
Hs

1 594
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Last updated: 15 Jul 2024