HitPredict

Interactor 1: BIK (Q13323)
Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4)
Gene: BIK

Interactor 2: B2CL2 (Q92843)
Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)
Gene: BCL2L2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	30217970, 27107012, 32296183, 25416956, 16697956, 10381646, unassigned1304, 15694340
Identification Methods	two hybrid, unspecified method, affinity chromatography technology, fluorescence polarization spectroscopy, two hybrid prey pooling approach, two hybrid array, validated two hybrid, barcode fusion genetics two hybrid, split luciferase complementation, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042981 - regulation of apoptotic process GO:0097136 - Bcl-2 family protein complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 160 Hs			1 193
+	Hs
		489410 BIK_HUMAN (1-160): 3.76e-101: 288: 100.00		BCL2_HUMAN (9-193): 1.75e-61: 192: 35.32
+	Hs
		992072 BIK_HUMAN (1-160): 3.76e-101: 288: 100.00		B2CL1_HUMAN (6-185): 1.44e-56: 179: 38.96
+	Hs
		992160 BIK_HUMAN (1-160): 3.76e-101: 288: 100.00		MCL1_HUMAN (19-180): 6.36e-46: 156: 21.82
+	Hs
		1031735 BIK_HUMAN (1-160): 3.76e-101: 288: 100.00		B2LA1_HUMAN (20-152): 1.24e-41: 139: 19.29
+	Hs
		1031797 BIK_HUMAN (1-160): 3.76e-101: 288: 100.00		B2L10_HUMAN (1-180): 1.23e-32: 117: 21.50
+	Hs
		3078 BIK_HUMAN (1-160): 3.76e-101: 288: 100.00		A0A0S2Z3D2_HUMAN (6-82): 6.96e-12: 62.5: 31.75