HitPredict

Interactor 1: MTA1 (Q13330)
Metastasis-associated protein MTA1
Gene: MTA1

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 27098840, 12920132, 29997244, 11146623, 16511565, 17922035, 21670149, 26496610, 28514442, 26949739, 24981860, 33961781, 33264408, 35271311, 20585571, 9885572, 21258344, 23752268, 26028330, 18451879
Identification Methods affinity chromatography technology, pull down, x-ray crystallography, chromatin immunoprecipitation assay, anti tag coimmunoprecipitation, cross-linking study, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 12 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024