HitPredict

Interactor 1: MTA1 (Q13330)
Metastasis-associated protein MTA1
Gene: MTA1

Interactor 2: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	28861931, 30118695
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0046872 - metal ion binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 715 Hs			1 630
+	Hs
		1031888 MTA1_HUMAN (1-715): 0: 939: 100.00		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		296023 MTA2_HUMAN (1-715): 0: 741: 57.55		TRI14_HUMAN (155-624): 1.74e-75: 249: 18.45
+	Hs
		296057 MTA2_HUMAN (1-715): 0: 741: 57.55		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		296176 MTA2_HUMAN (1-715): 0: 741: 57.55		TRI35_HUMAN (9-80): 1.95e-10: 65.5: 45.21
+	Hs
		1350407 RCOR3_HUMAN (167-532): 3.91e-75: 252: 17.71		TRIM1_HUMAN (3-629): 8.74e-115: 361: 20.58
+	Hs
		1223393 RERE_HUMAN (5-654): 1.84e-111: 371: 21.90		TRI22_HUMAN (6-291): 7.57e-31: 128: 16.50
+	Hs
		1172208 RCOR1_HUMAN (165-532): 5.9e-67: 230: 18.60		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		537110 RCOR3_HUMAN (167-532): 3.91e-75: 252: 17.71		TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40
+	Hs
		536888 MDEAS_HUMAN (157-483): 5.94e-46: 178: 14.17		TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40