HitPredict

Interactor 1: PTPRS (Q13332)
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
Gene: PTPRS

Interactor 2: PCD12 (Q9NPG4)
Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form]
Gene: PCDH12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1948 Hs			1 1184
+	Hs
		490026 PTPRF_HUMAN (1-1948): 0: 1528: 65.42		PCD12_HUMAN (26-1184): 0: 1280: 100.00
+	Hs
		1032047 PTPRS_HUMAN (1-1948): 0: 1690: 100.00		PCDG7_HUMAN (1-557): 5.39e-125: 409: 24.66
+	Hs
		1032046 PTPRS_HUMAN (1-1948): 0: 1690: 100.00		PCDGD_HUMAN (137-1095): 7.03e-116: 384: 19.06
+	Hs
		490044 PTPRF_HUMAN (1-1948): 0: 1528: 65.42		PCDGD_HUMAN (137-1095): 7.03e-116: 384: 19.06
+	Hs
		490028 PTPRF_HUMAN (1-1948): 0: 1528: 65.42		PCDBG_HUMAN (362-948): 4.44e-67: 244: 17.16
+	Hs
		617035 PTPRD_HUMAN (4-1463): 1.86e-106: 381: 16.51		PCDG6_HUMAN (2-834): 0: 824: 30.09
+	Hs
		617151 PTPRG_HUMAN (858-1945): 0: 786: 25.86		PCDGK_HUMAN (90-564): 1.37e-30: 132: 28.63
+	Hs
		1123263 SDK2_HUMAN (3-1422): 1.73e-122: 432: 16.47		PCDGD_HUMAN (137-1095): 7.03e-116: 384: 19.06
+	Hs
		617032 PTPRD_HUMAN (4-1463): 1.86e-106: 381: 16.51		PCDGG_HUMAN (3-452): 8.06e-99: 337: 26.30
+	Hs
		617023 PTPRD_HUMAN (4-1463): 1.86e-106: 381: 16.51		PCDBG_HUMAN (362-948): 4.44e-67: 244: 17.16
+	Hs
		617034 PTPRD_HUMAN (4-1463): 1.86e-106: 381: 16.51		PCDB1_HUMAN (120-558): 4.48e-33: 140: 27.82
+	Hs
		1269198 PTPRU_HUMAN (211-781): 3.44e-19: 97.4: 14.71		PCDGD_HUMAN (137-1095): 7.03e-116: 384: 19.06
+	Hs
		1069995 PTPRK_HUMAN (113-670): 1.42e-10: 68.9: 15.72		PCDGD_HUMAN (137-1095): 7.03e-116: 384: 19.06
+	Hs
		617033 PTPRD_HUMAN (4-1463): 1.86e-106: 381: 16.51		PCDB6_HUMAN (640-953): 1.75e-09: 64.3: 12.32
+	Hs
		1269189 PTPRU_HUMAN (211-781): 3.44e-19: 97.4: 14.71		PCDGG_HUMAN (3-452): 8.06e-99: 337: 26.30
+	Hs
		1069992 PTPRK_HUMAN (113-670): 1.42e-10: 68.9: 15.72		PCDGG_HUMAN (3-452): 8.06e-99: 337: 26.30
+	Hs
		1269196 PTPRU_HUMAN (211-781): 3.44e-19: 97.4: 14.71		PCDB3_HUMAN (362-803): 1.42e-50: 194: 20.48