HitPredict

Interactor 1: CTBP1 (Q13363)
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)
Gene: CTBP1

Interactor 2: IKZF1 (Q13422)
DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
Gene: IKZF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	25416956, 10766745, 27107012, 21900206, 24722188
Identification Methods	two hybrid, pull down, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, barcode fusion genetics two hybrid, split luciferase complementation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0019904 - protein domain specific binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 519
+	Hs
		881163 CTBP2_HUMAN (10-439): 0: 538: 80.23		IKZF1_HUMAN (1-519): 0: 664: 100.00
+	Rn
		88975 CTBP1_RAT (14-440): 0: 526: 98.36		D4A9W4_RAT (1-519): 0: 614: 89.05
+	Hs
		1032673 CTBP1_HUMAN (1-440): 0: 547: 100.00		IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74
+	Hs
		1032605 CTBP1_HUMAN (1-440): 0: 547: 100.00		IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26
+	Hs
		881332 CTBP2_HUMAN (10-439): 0: 538: 80.23		IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74
+	Hs
		881333 CTBP2_HUMAN (10-439): 0: 538: 80.23		IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82
+	Mm
		292178 CTBP1_MOUSE (1-440): 0: 545: 98.64		Q8C5P6_MOUSE (1-254): 8.48e-111: 331: 94.88
+	Mm
		881367 CTBP2_MOUSE (10-439): 0: 535: 80.00		Q8C5P6_MOUSE (1-254): 8.48e-111: 331: 94.88