HitPredict

Interactor 1: CTBP1 (Q13363)
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)
Gene: CTBP1

Interactor 2: TSH3 (Q63HK5)
Teashirt homolog 3 (Zinc finger protein 537)
Gene: TSHZ3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	25416956, 35016035
Identification Methods	two hybrid, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 1081
+	Hs
		881200 CTBP2_HUMAN (10-439): 0: 538: 80.23		TSH3_HUMAN (1-1081): 0: 1011: 100.00
+	Hs
		1032482 CTBP1_HUMAN (1-440): 0: 547: 100.00		TSH1_HUMAN (1-1081): 0: 908: 53.71
+	Hs
		1032408 CTBP1_HUMAN (1-440): 0: 547: 100.00		MDC1_HUMAN (414-919): 2.78e-12: 73.5: 12.55
+	Hs
		1032721 CTBP1_HUMAN (1-440): 0: 547: 100.00		PCLO_HUMAN (307-914): 3.64e-10: 66.7: 8.55
+	Dm
		220626 CTBP_DROME (1-361): 1.59e-142: 417: 70.91		TSH_DROME (266-787): 1.02e-34: 146: 15.01
+	Hs
		197305 SERA_HUMAN (29-404): 9.81e-121: 363: 29.23		MDC1_HUMAN (414-919): 2.78e-12: 73.5: 12.55
+	Hs
		197363 SERA_HUMAN (29-404): 9.81e-121: 363: 29.23		TITIN_HUMAN (492-941): 5.51e-10: 66.3: 8.49