HitPredict

Interactor 1: UB2V1 (Q13404)
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)
Gene: UBE2V1

Interactor 2: ZNRF1 (Q8ND25)
E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)
Gene: ZNRF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 227
+	Hs
		1079004 UB2V2_HUMAN (4-147): 8.54e-72: 213: 88.89		ZNRF1_HUMAN (1-227): 1.18e-130: 369: 100.00
+	Hs
		1242076 UB2D4_HUMAN (12-146): 4.26e-58: 178: 24.44		ZNRF1_HUMAN (1-227): 1.18e-130: 369: 100.00
+	Hs
		849373 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		ZNRF1_HUMAN (1-227): 1.18e-130: 369: 100.00
+	Hs
		919790 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		ZNRF1_HUMAN (1-227): 1.18e-130: 369: 100.00
+	Hs
		895849 UB2D3_HUMAN (12-146): 3.82e-56: 173: 22.96		ZNRF1_HUMAN (1-227): 1.18e-130: 369: 100.00
+	Hs
		1242072 UB2E3_HUMAN (1-145): 1.38e-54: 172: 22.76		ZNRF1_HUMAN (1-227): 1.18e-130: 369: 100.00
+	Hs
		1242075 UB2E2_HUMAN (2-145): 1.8e-54: 171: 23.61		ZNRF1_HUMAN (1-227): 1.18e-130: 369: 100.00
+	Hs
		851849 UB2E1_HUMAN (7-124): 1.45e-12: 63.8: 29.37		ZNRF1_HUMAN (1-227): 1.18e-130: 369: 100.00
+	Hs
		1243628 UB2D4_HUMAN (12-146): 4.26e-58: 178: 24.44		Q8NEX1_HUMAN (46-227): 8.11e-77: 231: 50.55
+	Hs
		849374 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		Q8NEX1_HUMAN (46-227): 8.11e-77: 231: 50.55
+	Hs
		919791 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		Q8NEX1_HUMAN (46-227): 8.11e-77: 231: 50.55
+	Hs
		895850 UB2D3_HUMAN (12-146): 3.82e-56: 173: 22.96		Q8NEX1_HUMAN (46-227): 8.11e-77: 231: 50.55
+	Hs
		1245518 UB2D4_HUMAN (12-146): 4.26e-58: 178: 24.44		ZNRF2_HUMAN (51-227): 9.84e-74: 225: 49.72
+	Hs
		849375 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		ZNRF2_HUMAN (51-227): 9.84e-74: 225: 49.72
+	Hs
		919793 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		ZNRF2_HUMAN (51-227): 9.84e-74: 225: 49.72
+	Hs
		895853 UB2D3_HUMAN (12-146): 3.82e-56: 173: 22.96		ZNRF2_HUMAN (51-227): 9.84e-74: 225: 49.72
+	Hs
		1245509 UB2E3_HUMAN (1-145): 1.38e-54: 172: 22.76		ZNRF2_HUMAN (51-227): 9.84e-74: 225: 49.72
+	Hs
		1245511 UB2E2_HUMAN (2-145): 1.8e-54: 171: 23.61		ZNRF2_HUMAN (51-227): 9.84e-74: 225: 49.72
+	Hs
		1033125 UB2V1_HUMAN (1-147): 1.08e-54: 170: 100.00		ZNRF2_HUMAN (51-227): 9.84e-74: 225: 49.72
+	Hs
		851850 UB2E1_HUMAN (7-124): 1.45e-12: 63.8: 29.37		ZNRF2_HUMAN (51-227): 9.84e-74: 225: 49.72