HitPredict

Interactor 1: UB2V1 (Q13404)
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)
Gene: UBE2V1

Interactor 2: ZNRF2 (Q8NHG8)
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)
Gene: ZNRF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	32265276
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 242
+	Hs
		1079004 UB2V2_HUMAN (4-147): 8.54e-72: 213: 88.89		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1242076 UB2D4_HUMAN (12-146): 4.26e-58: 178: 24.44		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		849373 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		919790 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		895849 UB2D3_HUMAN (12-146): 3.82e-56: 173: 22.96		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1242072 UB2E3_HUMAN (1-145): 1.38e-54: 172: 22.76		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1242075 UB2E2_HUMAN (2-145): 1.8e-54: 171: 23.61		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1033123 UB2V1_HUMAN (1-147): 1.08e-54: 170: 100.00		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1245518 UB2D4_HUMAN (12-146): 4.26e-58: 178: 24.44		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		849375 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		919793 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		895853 UB2D3_HUMAN (12-146): 3.82e-56: 173: 22.96		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		1245509 UB2E3_HUMAN (1-145): 1.38e-54: 172: 22.76		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		1245511 UB2E2_HUMAN (2-145): 1.8e-54: 171: 23.61		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		1243628 UB2D4_HUMAN (12-146): 4.26e-58: 178: 24.44		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		849374 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		919791 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		895850 UB2D3_HUMAN (12-146): 3.82e-56: 173: 22.96		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		851849 UB2E1_HUMAN (7-124): 1.45e-12: 63.8: 29.37		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		851850 UB2E1_HUMAN (7-124): 1.45e-12: 63.8: 29.37		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00