HitPredict

Interactor 1: UB2V1 (Q13404)
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)
Gene: UBE2V1

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20804422
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030154 - cell differentiation and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 757
+	Hs
		849452 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		849451 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		1294888 UB2D4_HUMAN (12-146): 4.26e-58: 178: 24.44		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		849411 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		135948 UBE2C_HUMAN (2-147): 2.51e-56: 175: 25.17		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		919827 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Sc
		765333 MMS2_YEAST (10-145): 1.52e-61: 187: 50.00		RSP5_YEAST (13-757): 0: 712: 36.40
+	Hs
		125808 UB2D4_HUMAN (12-146): 4.26e-58: 178: 24.44		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125262 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125335 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Sp
		145419 UBC4_SCHPO (12-146): 1.27e-56: 175: 23.70		PUB3_SCHPO (12-757): 0: 700: 35.23
+	Hs
		808052 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		808078 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		849353 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Hs
		919765 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Hs
		849416 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		919834 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		849444 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		849351 UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27		HECW1_HUMAN (2-213): 2.55e-19: 95.6: 15.28
+	Hs
		919762 UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96		HECW1_HUMAN (2-213): 2.55e-19: 95.6: 15.28