HitPredict

Interactor 1: IKZF1 (Q13422)
DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
Gene: IKZF1

Interactor 2: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 519 Hs			1 745
+	Hs
		983757 ZNF91_HUMAN (33-518): 6.36e-161: 489: 14.93		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		73014 B4DU56_HUMAN (2-416): 3.08e-164: 480: 14.59		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1041954 ZN227_HUMAN (39-518): 9.75e-160: 475: 15.31		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1041578 ZN268_HUMAN (35-519): 6.3e-149: 452: 15.35		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1041826 Z585A_HUMAN (77-518): 3.08e-151: 452: 14.00		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		846676 ZNF84_HUMAN (86-518): 3.19e-150: 449: 13.75		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1043300 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		563252 ZNF12_HUMAN (1-413): 1.96e-135: 409: 15.37		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1041764 ZN658_HUMAN (2-260): 5.47e-99: 323: 18.42		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1042799 ZN229_HUMAN (2-253): 2.34e-99: 319: 20.16		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		988832 ZN33B_HUMAN (55-519): 2.89e-93: 302: 11.09		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		988826 ZN33A_HUMAN (55-519): 2.11e-92: 300: 11.73		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1042755 ZN629_HUMAN (292-518): 1.03e-88: 292: 11.89		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1042724 ZN624_HUMAN (287-518): 3.13e-70: 242: 12.00		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		299538 ZN432_HUMAN (231-519): 7.02e-58: 205: 11.53		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1041738 ZN569_HUMAN (360-519): 8.2e-51: 186: 13.13		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1042371 ZN184_HUMAN (386-519): 1.58e-43: 166: 15.67		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1042693 RBAK_HUMAN (287-516): 2.36e-24: 109: 10.88		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		565092 ZNF7_HUMAN (1-113): 5.47e-19: 92.3: 8.85		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1042028 ZN808_HUMAN (2-87): 8.67e-18: 89.1: 5.81		CUL3_HUMAN (1-745): 0: 768: 26.38