HitPredict

Interactor 1: IKZF1 (Q13422)
DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
Gene: IKZF1

Interactor 2: LMO3 (Q8TAP4)
LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3)
Gene: LMO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 519 Hs			1 145
+	Hs
		638281 IKZF1_HUMAN (1-519): 0: 664: 100.00		RBTN2_HUMAN (13-133): 8.21e-46: 148: 60.33
+	Hs
		903710 IKZF1_HUMAN (1-519): 0: 664: 100.00		LMO4_HUMAN (11-142): 3.16e-41: 136: 50.76
+	Hs
		638501 IKZF1_HUMAN (1-519): 0: 664: 100.00		RBTN1_HUMAN (1-133): 5.2e-37: 125: 95.49
+	Hs
		1033698 IKZF1_HUMAN (1-519): 0: 664: 100.00		LHX4_HUMAN (72-144): 4.55e-12: 63.8: 19.18
+	Hs
		855972 ZN135_HUMAN (2-456): 3.86e-154: 456: 15.70		LMO4_HUMAN (11-142): 3.16e-41: 136: 50.76
+	Hs
		638487 ZNF84_HUMAN (86-518): 3.19e-150: 449: 13.75		RBTN1_HUMAN (1-133): 5.2e-37: 125: 95.49
+	Hs
		846679 ZNF84_HUMAN (86-518): 3.19e-150: 449: 13.75		LMO3_HUMAN (1-145): 3.61e-37: 125: 100.00
+	Hs
		638423 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		RBTN2_HUMAN (13-133): 8.21e-46: 148: 60.33
+	Hs
		903791 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		LMO4_HUMAN (11-142): 3.16e-41: 136: 50.76
+	Hs
		638592 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		RBTN1_HUMAN (1-133): 5.2e-37: 125: 95.49
+	Hs
		903785 RBAK_HUMAN (287-516): 2.36e-24: 109: 10.88		LMO4_HUMAN (11-142): 3.16e-41: 136: 50.76
+	Hs
		638344 ZNF34_HUMAN (117-224): 1.15e-16: 84.7: 37.04		RBTN2_HUMAN (13-133): 8.21e-46: 148: 60.33
+	Dm
		114398 CF2_DROME (117-191): 1.44e-10: 65.5: 41.33		M9PCA3_DROME (12-140): 8.6e-44: 153: 37.69
+	Dm
		592803 CF2_DROME (117-191): 1.44e-10: 65.5: 41.33		Q9VTW5_DROME (12-140): 8.67e-44: 153: 37.69
+	Hs
		903756 ZN397_HUMAN (118-197): 2.27e-11: 68.2: 37.50		LMO4_HUMAN (11-142): 3.16e-41: 136: 50.76
+	Hs
		1251439 ZIM3_HUMAN (118-224): 2.19e-14: 77.4: 33.65		LMO3_HUMAN (1-145): 3.61e-37: 125: 100.00
+	Hs
		1078405 ZKSC8_HUMAN (118-171): 1.71e-09: 62.4: 51.85		LMO3_HUMAN (1-145): 3.61e-37: 125: 100.00
+	Hs
		1332089 IKZF5_HUMAN (62-193): 1.16e-11: 68.6: 33.33		PDLI7_HUMAN (70-145): 5.47e-15: 72.3: 23.68
+	Hs
		822633 OZF_HUMAN (118-196): 2.3e-12: 69.7: 37.98		LHX1_HUMAN (4-67): 3.28e-11: 61.5: 26.15
+	Hs
		1332093 IKZF5_HUMAN (62-193): 1.16e-11: 68.6: 33.33		LHX3_HUMAN (4-68): 2.41e-11: 61.9: 21.21