HitPredict

Interactor 1: IKZF1 (Q13422)
DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
Gene: IKZF1

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	11959865, 10357820, 12015313
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 519 Hs			1 1273
+	Hs
		1302473 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		1302443 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		1302474 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		257778 IKZF1_HUMAN (1-519): 0: 664: 100.00		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257848 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257833 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257849 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15