HitPredict

Interactor 1: G4S034 (G4S034)
Spectrin alpha chain
Gene: spc-1

Interactor 2: G5ECP9 (G5ECP9)
Spectrin beta chain
Gene: vab-10

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	31462781
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin, SH3_10~Spectrin
Common GO terms	GO:0051015 - actin filament binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2427 Ce			1 3424
+	Ce
		103420 G4S034_CAEEL (1-2427): 3.72e-175: 600: 100.00		G5EG85_CAEEL (278-821): 2.34e-16: 88.9: 14.16
+	Hs
		70396 ACTN4_HUMAN (1940-2425): 1.45e-72: 265: 33.13		B2R8Y4_HUMAN (27-770): 9.95e-100: 347: 21.32
+	Hs
		211571 ACTN4_HUMAN (1940-2425): 1.45e-72: 265: 33.13		ACTN3_HUMAN (27-770): 3.46e-99: 345: 21.45
+	Rn
		555258 SPTN1_RAT (3-1971): 1.41e-63: 244: 19.12		Q6XD99_RAT (7-2014): 9.25e-94: 343: 14.74
+	Hs
		211478 ACTN4_HUMAN (1940-2425): 1.45e-72: 265: 33.13		ACTN1_HUMAN (10-766): 6.52e-86: 305: 20.23
+	Hs
		963320 SPTN1_HUMAN (4-1743): 7.39e-59: 228: 20.85		SPTB2_HUMAN (7-2076): 6.34e-89: 328: 14.89
+	Hs
		164614 SPTN1_HUMAN (4-1743): 7.39e-59: 228: 20.85		SPTN2_HUMAN (22-2121): 1.62e-87: 323: 15.02
+	Rn
		555261 SPTN1_RAT (3-1971): 1.41e-63: 244: 19.12		ACTN1_RAT (10-766): 3.87e-86: 306: 20.35
+	Hs
		1045513 SPTN1_HUMAN (4-1743): 7.39e-59: 228: 20.85		SPTN4_HUMAN (10-2145): 4.8e-86: 318: 13.82
+	Dm
		527092 SPTCA_DROME (1-1423): 8.12e-40: 165: 18.45		SPTCB_DROME (7-1800): 6.36e-105: 380: 16.53
+	Hs
		506818 SPTN1_HUMAN (4-1743): 7.39e-59: 228: 20.85		SPTB1_HUMAN (13-2144): 7.07e-84: 311: 15.12
+	Hs
		211430 ACTN4_HUMAN (1940-2425): 1.45e-72: 265: 33.13		ACTN4_HUMAN (41-365): 1.27e-55: 214: 40.00
+	Rn
		1167662 Q6XD99_RAT (1-859): 1.59e-40: 167: 22.16		ACTN1_RAT (10-766): 3.87e-86: 306: 20.35
+	Hs
		1045418 SPTN1_HUMAN (4-1743): 7.39e-59: 228: 20.85		PLEC_HUMAN (2335-3041): 1.32e-29: 132: 11.63
+	Mm
		93541 SPTA1_MOUSE (1-1861): 2.11e-47: 190: 17.91		DESP_MOUSE (271-1085): 2e-18: 95.9: 8.44
+	Mm
		434793 SPTA1_MOUSE (1-1861): 2.11e-47: 190: 17.91		DMD_MOUSE (1044-2456): 1.08e-12: 77.1: 8.02
+	Dm
		54298 Q7KV70_DROME (595-2359): 2.68e-43: 177: 14.94		A1Z9J2_DROME (276-1310): 4.04e-13: 78.6: 9.39
+	Dm
		54289 A1Z9J2_DROME (902-2272): 1.41e-40: 168: 13.23		A1Z9J2_DROME (276-1310): 4.04e-13: 78.6: 9.39
+	Dm
		54294 SPTCA_DROME (1-1423): 8.12e-40: 165: 18.45		A1Z9J2_DROME (276-1310): 4.04e-13: 78.6: 9.39