HitPredict

Interactor 1: ADAM9 (Q13443)
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase)
Gene: ADAM9

Interactor 2: PACN3 (Q9UKS6)
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)
Gene: PACSIN3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.60	0.506

Property	Details
Experiments	10531379
Identification Methods	two hybrid, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0051044 - positive regulation of membrane protein ectodomain proteolysis GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 819 Hs			1 424
+	Mm
		1142117 ADAM9_MOUSE (1-819): 0: 671: 81.54		PACN3_MOUSE (1-424): 1.36e-93: 290: 94.34
+	Hs
		197625 ADA12_HUMAN (26-815): 1.49e-172: 523: 35.50		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		1356560 ADA18_HUMAN (30-746): 1.71e-151: 463: 32.47		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		1034780 ADA15_HUMAN (55-800): 4.78e-143: 445: 31.43		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Mm
		292358 ADA15_MOUSE (32-800): 2.6e-131: 414: 30.77		PACN3_MOUSE (1-424): 1.36e-93: 290: 94.34
+	Hs
		941711 ADAM8_HUMAN (18-814): 3.37e-170: 514: 30.63		CIP4_HUMAN (16-365): 9.77e-38: 146: 17.05
+	Hs
		197601 ADA12_HUMAN (26-815): 1.49e-172: 523: 35.50		ITSN1_HUMAN (30-424): 3.23e-15: 80.2: 10.78
+	Hs
		1132434 ADA19_HUMAN (8-816): 5.44e-170: 518: 32.29		FBP1L_HUMAN (190-421): 1.92e-12: 70.9: 13.82
+	Hs
		941713 ADAM8_HUMAN (18-814): 3.37e-170: 514: 30.63		FBP1L_HUMAN (190-421): 1.92e-12: 70.9: 13.82
+	Hs
		941717 ADAM8_HUMAN (18-814): 3.37e-170: 514: 30.63		FNBP1_HUMAN (214-421): 7.83e-12: 69: 13.46
+	Hs
		305115 ADA19_HUMAN (8-816): 5.44e-170: 518: 32.29		RIMB1_HUMAN (280-423): 2.01e-09: 62.1: 18.71
+	Hs
		1034753 ADA15_HUMAN (55-800): 4.78e-143: 445: 31.43		ITSN1_HUMAN (30-424): 3.23e-15: 80.2: 10.78
+	Hs
		152352 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		944529 ADA17_HUMAN (140-517): 2.96e-19: 95.1: 24.61		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		152327 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		PACN1_HUMAN (4-422): 1.04e-84: 267: 48.86
+	Hs
		944521 ADA17_HUMAN (140-517): 2.96e-19: 95.1: 24.61		PACN1_HUMAN (4-422): 1.04e-84: 267: 48.86
+	Hs
		152353 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		PACN2_HUMAN (4-422): 2.86e-77: 249: 48.96
+	Hs
		152206 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		PPIP1_HUMAN (7-422): 4.41e-64: 213: 21.48
+	Hs
		152280 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		MYO1E_HUMAN (2-422): 5.28e-39: 151: 14.03
+	Hs
		152211 ADA10_HUMAN (51-517): 7.81e-24: 109: 25.14		GAS7_HUMAN (363-422): 5.06e-10: 63.1: 34.43